Version 5.4
Homo sapiens Gene: RAD51B
Summary
InnateDB Gene IDBG-10135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD51B
Gene Name RAD51 homolog B (S. cerevisiae)
Synonyms R51H2; RAD51L1; REC2
Species Homo sapiens
Ensembl Gene ENSG00000182185
Encoded Proteins
IDBP-10141
RAD51 homolog B (S. cerevisiae)
IDBP-479988
RAD51 homolog B (S. cerevisiae)
IDBP-475879
RAD51 homolog B (S. cerevisiae)
IDBP-482376
RAD51 homolog B (S. cerevisiae)
IDBP-483584
RAD51 homolog B (S. cerevisiae)
IDBP-479452
RAD51 homolog B (S. cerevisiae)
IDBP-476144
RAD51 homolog B (S. cerevisiae)
IDBP-603569
RAD51 homolog B (S. cerevisiae)
IDBP-599540
RAD51 homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67819779-68730218
Strand Forward strand
Band q24.1
Transcripts
ENST00000390683 ENSP00000375101
ENST00000487861 ENSP00000419881
ENST00000479335 ENSP00000417408
ENST00000471583 ENSP00000418859
ENST00000487270 ENSP00000419471
ENST00000488612 ENSP00000420061
ENST00000485181 ENSP00000417948
ENST00000474051
ENST00000497460
ENST00000492236
ENST00000478014
ENST00000469165
ENST00000460526
ENST00000468382
ENST00000553334 ENSP00000452044
ENST00000553734
ENST00000555907
ENST00000553595
ENST00000554244
ENST00000557045
ENST00000554183
ENST00000554575 ENSP00000451616
ENST00000555782
ENST00000556251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0007131 reciprocal meiotic recombination
GO:0007596 blood coagulation
GO:0009432 SOS response
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059060
View Gene Order
ENSBTAG00000018971
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.172587 Hs.574183 Hs.624879
RefSeq NM_002877 NM_133509 NM_133510
HUGO
OMIM
CCDS CCDS9789 CCDS9790
HPRD 04255
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca