InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FCGR1A

Summary

InnateDB Gene

IDBG-101961.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR1A

Gene Name

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Synonyms

CD64; CD64A; FCRI; IGFR1

Species

Homo sapiens

Ensembl Gene

ENSG00000150337

Encoded Proteins

IDBP-101963

Fc fragment of IgG, high affinity Ia, receptor (CD64)

IDBP-388276

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21044955

FCGR1A (FcgammaRI) is a receptor that recognizes IgG opsonized particles and initiates phagocytosis in immune clearance. FCGR1A is also a negative regulator of complement-mediated phagocytosis.

Entrez Gene

Summary

Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:149782671-149792518

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000369168	ENSP00000358165
ENST00000444948	ENSP00000394279
ENST00000489479
ENST00000489704

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006911	phagocytosis, engulfment
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031901	early endosome membrane