InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCGR1A

Summary

InnateDB Protein

IDBP-101963.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR1A

Protein Name

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Synonyms

CD64; CD64A; FCRI; IGFR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000358165

InnateDB Gene

IDBG-101961 (FCGR1A)

Protein Structure

UniProt Annotation

Function

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269PubMed:10397749, ECO:0000269PubMed:10514529, ECO:0000269PubMed:21965667, ECO:0000269PubMed:8611682, ECO:0000269PubMed:9881690}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12756162, ECO:0000269PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269PubMed:12756162, ECO:0000269PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G.

Disease Associations

Tissue Specificity

Monocyte/macrophage specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006911	phagocytosis, engulfment
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031901	early endosome membrane