Homo sapiens Gene: HIST2H2AB

Summary
InnateDB Gene IDBG-102016.4
Last Modified 2011-02-17   [Report errors or provide feedback]
Gene Symbol HIST2H2AB
Gene Name histone cluster 2, H2ab
Synonyms H2AB
Species Homo sapiens
Ensembl Gene ENSG00000184270
Encoded Proteins
IDBP-102018 histone cluster 2, H2ab
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 149859019-149859466
Strand Reverse strand
Band q21.2
Transcripts
ENST00000331128  ENSP00000332790
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein‑Protein  7
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000063689 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000038476 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa05322  Systemic lupus erythematosus
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8IUE6 
TrEMBL
UniProt Splice Variant
Entrez Gene 317772 
UniGene Hs.664173
RefSeq NM_175065 
HUGO 20508 
OMIM
CCDS CCDS938 
HPRD 13659
IMGT
EMBL AL591493 AY131972
GenPept AAN59958  CAI12570 
ImmGen HIST2H2AB (murine) 
RNA Seq Atlas 317772