Homo sapiens Gene: HIST2H2AB
Summary
InnateDB Gene IDBG-102016.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST2H2AB
Gene Name histone cluster 2, H2ab
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184270
Encoded Proteins
histone cluster 2, H2ab
Protein Structure
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:149887524-149887916
Strand Reverse strand
Band q21.2
Transcripts
ENST00000331128 ENSP00000332790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
KEGG
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8IUE6
TrEMBL V9GZN0
UniProt Splice Variant
Entrez Gene 317772
UniGene Hs.664173
RefSeq NM_175065
HUGO HGNC:20508
OMIM 615014
CCDS CCDS938
HPRD 13659
IMGT
EMBL AL591493 AY131972 K01889
GenPept AAA35945 AAN59958 CAI12570
ImmGen HIST2H2AB (murine)
RNA Seq Atlas 317772