Homo sapiens Gene: CA14
Summary
InnateDB Gene IDBG-102068.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA14
Gene Name carbonic anhydrase XIV
Synonyms CAXiV
Species Homo sapiens
Ensembl Gene ENSG00000118298
Encoded Proteins
carbonic anhydrase XIV
carbonic anhydrase XIV
carbonic anhydrase XIV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150257159-150265078
Strand Forward strand
Band q21.2
Transcripts
ENST00000369111 ENSP00000358107
ENST00000483993 ENSP00000475869
ENST00000582010
ENST00000607652
ENST00000607082 ENSP00000475238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0046872 metal ion binding
Biological Process
GO:0015701 bicarbonate transport
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Reversible hydration of carbon dioxide pathway
Metabolism pathway
KEGG
Nitrogen metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528988
RefSeq NM_012113 XM_005245059
HUGO
OMIM
CCDS CCDS947
HPRD 05320
IMGT
EMBL
GenPept
RNA Seq Atlas