Version 5.4
Homo sapiens Gene: CGN
Summary
InnateDB Gene IDBG-102382.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CGN
Gene Name cingulin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143375
Encoded Proteins
IDBP-102386
cingulin
IDBP-388578
cingulin
IDBP-388579
cingulin
IDBP-475831
cingulin
IDBP-479480
cingulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151510510-151538692
Strand Forward strand
Band q21.3
Transcripts
ENST00000271636 ENSP00000271636
ENST00000427934 ENSP00000410836
ENST00000416743 ENSP00000390686
ENST00000505188 ENSP00000425532
ENST00000502442 ENSP00000422299
ENST00000464886
ENST00000473377
ENST00000467998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005923 tight junction
GO:0016459 myosin complex
GO:0030054 cell junction
GO:0043296 apical junction complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068876
View Gene Order
ENSBTAG00000017564
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 57530
UniGene Hs.18376 Hs.705768
RefSeq NM_020770 XM_005245365 XM_006711470
HUGO HGNC:17429
OMIM 609473
CCDS CCDS999
HPRD 10827
IMGT
EMBL
GenPept
RNA Seq Atlas 57530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca