Version 5.4
Homo sapiens Protein: CGN
Summary
InnateDB Protein IDBP-102386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CGN
Protein Name cingulin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000271636
InnateDB Gene IDBG-102382 (CGN)
Protein Structure
UniProt Annotation
Function Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Subcellular Localization Cell junction, tight junction {ECO:0000250}. Note=Localizes to the apical junction complex composed of tight and adherens junctions. {ECO:0000250}.
Disease Associations
Tissue Specificity Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005923 tight junction
GO:0016459 myosin complex
GO:0030054 cell junction
GO:0043296 apical junction complex
Protein Structure and Domains
PDB ID
InterPro IPR002928 Myosin tail
PFAM PF01576
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2M7
PhosphoSite PhosphoSite-Q9P2M7
TrEMBL A6PVU7
UniProt Splice Variant
Entrez Gene 57530
UniGene Hs.705768
RefSeq NP_065821
HUGO HGNC:17429
OMIM 609473
CCDS CCDS999
HPRD 10827
IMGT
EMBL AB037740 AF263462 AK290007 AL365436 BC146657 BC152445 CH471121
GenPept AAF74498 AAI46658 AAI52446 BAA92557 BAF82696 CAI16590 EAW53434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca