Version 5.4
Homo sapiens Gene: RORC
Summary
InnateDB Gene IDBG-102434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RORC
Gene Name RAR-related orphan receptor C
Synonyms NR1F3; RORG; RZR-GAMMA; RZRG; TOR
Species Homo sapiens
Ensembl Gene ENSG00000143365
Encoded Proteins
IDBP-102438
RAR-related orphan receptor C
IDBP-102440
RAR-related orphan receptor C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26187413
Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.
InnateDB Annotation from Orthologs
Summary
PMID 24419270
[Mus musculus] Gata3 plays a generalized role in innate lymphoid cell (ILC) lineage determination and is critical for the development of gut Rorc+ group 3 ILCs subsets that maintain mucosal barrier homeostasis.
PMID 24670648
[Mus musculus] Retinoic acid (RA) induces the maturation of lymphoid tissue inducer cells in developing lymph nodes by inducing RA receptor binding to the promoter region of Rorc.
PMID 26878233
[Mus musculus] Rorc is differentially required in the maintenance of TH17 cell and group 3 innate lymphoid cell responses.
Entrez Gene
Summary The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151806071-151831872
Strand Reverse strand
Band q21.3
Transcripts
ENST00000356728 ENSP00000349164
ENST00000318247 ENSP00000327025
ENST00000480719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008142 oxysterol binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0098531 direct ligand regulated sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006805 xenobiotic metabolic process
GO:0010467 gene expression
GO:0010906 regulation of glucose metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0032922 circadian regulation of gene expression
GO:0033077 T cell differentiation in thymus
GO:0036315 cellular response to sterol
GO:0042093 T-helper cell differentiation
GO:0042753 positive regulation of circadian rhythm
GO:0043401 steroid hormone mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045586 regulation of gamma-delta T cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0046632 alpha-beta T cell differentiation
GO:0048535 lymph node development
GO:0048537 mucosal-associated lymphoid tissue development
GO:0048541 Peyer's patch development
GO:0060612 adipose tissue development
GO:0060850 regulation of transcription involved in cell fate commitment
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0072539 T-helper 17 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028150
View Gene Order
ENSBTAG00000017405
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
Cross-References
SwissProt P51449
TrEMBL B6ZGS6 D3DV25 F1D8P6 Q6I9R9
UniProt Splice Variant
Entrez Gene 6097
UniGene Hs.256022
RefSeq NM_001001523 NM_005060 XM_005245424 XM_006711484
HUGO HGNC:10260
OMIM 602943
CCDS CCDS1004 CCDS30856
HPRD
IMGT
EMBL AB307696 AL589765 AL834219 BC031554 BC110571 CH471121 CR457436 HQ692834 U16997
GenPept AAA64751 AAH31554 AAI10572 ADZ17345 BAH02287 CAD38900 CAG33717 CAI17179 EAW53405 EAW53406
RNA Seq Atlas 6097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca