InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.49360

Summary

InnateDB Gene

IDBG-632995.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49360

Gene Name

nuclear receptor ROR-gamma

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017405

Encoded Proteins

IDBP-684660

nuclear receptor ROR-gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26187413

[Homo sapiens] Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.

PMID 24419270

[Mus musculus] Gata3 plays a generalized role in innate lymphoid cell (ILC) lineage determination and is critical for the development of gut Rorc+ group 3 ILCs subsets that maintain mucosal barrier homeostasis.

PMID 24670648

[Mus musculus] Retinoic acid (RA) induces the maturation of lymphoid tissue inducer cells in developing lymph nodes by inducing RA receptor binding to the promoter region of Rorc.

PMID 26878233

[Mus musculus] Rorc is differentially required in the maintenance of TH17 cell and group 3 innate lymphoid cell responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143365:
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:18991963-19015891

Strand

Forward strand

Band

Transcripts

ENSBTAT00000044130

ENSBTAP00000041645

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001223	transcription coactivator binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008142	oxysterol binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0098531	direct ligand regulated sequence-specific DNA binding transcription factor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006805	xenobiotic metabolic process
GO:0010906	regulation of glucose metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0030154	cell differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0033077	T cell differentiation in thymus
GO:0036315	cellular response to sterol
GO:0042093	T-helper cell differentiation
GO:0042753	positive regulation of circadian rhythm
GO:0043401	steroid hormone mediated signaling pathway
GO:0045586	regulation of gamma-delta T cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0046632	alpha-beta T cell differentiation
GO:0048535	lymph node development
GO:0048537	mucosal-associated lymphoid tissue development
GO:0048541	Peyer's patch development
GO:0060612	adipose tissue development
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0072539	T-helper 17 cell differentiation