Version 5.4
Homo sapiens Gene: S100A4
Summary
InnateDB Gene IDBG-102693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A4
Gene Name S100 calcium binding protein A4
Synonyms 18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98
Species Homo sapiens
Ensembl Gene ENSG00000196154
Encoded Proteins
IDBP-102695
S100 calcium binding protein A4
IDBP-102697
S100 calcium binding protein A4
IDBP-102699
S100 calcium binding protein A4
IDBP-102701
S100 calcium binding protein A4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153543613-153550136
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368716 ENSP00000357705
ENST00000354332 ENSP00000346294
ENST00000368715 ENSP00000357704
ENST00000368714 ENSP00000357703
ENST00000481009
ENST00000468373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
GO:0048306 calcium-dependent protein binding
GO:0050786 RAGE receptor binding
Biological Process
GO:0001837 epithelial to mesenchymal transition
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001020
View Gene Order
ENSBTAG00000019203
Not yet available
Cross-References
SwissProt P26447
TrEMBL
UniProt Splice Variant
Entrez Gene 6275
UniGene
RefSeq NM_002961 NM_019554
HUGO HGNC:10494
OMIM 114210
CCDS CCDS1042
HPRD
IMGT
EMBL AK292083 BC000838 BC016300 BX470102 CH471121 CR450345 M80563 Z18950 Z33457
GenPept AAA51920 AAH00838 AAH16300 BAF84772 CAA79474 CAA83880 CAG29341 CAI14754 EAW53310 EAW53311 EAW53312 EAW53313 EAW53314 EAW53315
RNA Seq Atlas 6275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca