Version 5.4
Homo sapiens Gene: CRTC2
Summary
InnateDB Gene IDBG-102803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRTC2
Gene Name CREB regulated transcription coactivator 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160741
Encoded Proteins
IDBP-102805
CREB regulated transcription coactivator 2
IDBP-102809
CREB regulated transcription coactivator 2
IDBP-102811
CREB regulated transcription coactivator 2
IDBP-593976
CREB regulated transcription coactivator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153947669-153958625
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368633 ENSP00000357622
ENST00000303569 ENSP00000305873
ENST00000368630 ENSP00000357619
ENST00000461638 ENSP00000434115
ENST00000487235
ENST00000467860
ENST00000493909
ENST00000476883
ENST00000492073
ENST00000524997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0016032 viral process
GO:0032793 positive regulation of CREB transcription factor activity
GO:0042593 glucose homeostasis
GO:0043970 histone H3-K9 acetylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051289 protein homotetramerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027936
View Gene Order
ENSBTAG00000017942
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.406392 Hs.610004
RefSeq NM_181715 XM_005244946 XM_005244949
HUGO
OMIM
CCDS CCDS30875
HPRD 12347
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca