InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRTC2

Summary

InnateDB Protein

IDBP-102805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRTC2

Protein Name

CREB regulated transcription coactivator 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357622

InnateDB Gene

IDBG-102803 (CRTC2)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269PubMed:14506290, ECO:0000269PubMed:14536081, ECO:0000269PubMed:15454081, ECO:0000269PubMed:16809310, ECO:0000269PubMed:16817901, ECO:0000269PubMed:16980408, ECO:0000269PubMed:17210223}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Disease Associations

Tissue Specificity

Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269PubMed:14536081, ECO:0000269PubMed:15454081, ECO:0000269PubMed:16980408}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008140	cAMP response element binding protein binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0016032	viral process
GO:0032793	positive regulation of CREB transcription factor activity
GO:0042593	glucose homeostasis
GO:0043970	histone H3-K9 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051289	protein homotetramerization