Version 5.4
Homo sapiens Gene: ASH1L
Summary
InnateDB Gene IDBG-103260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASH1L
Gene Name ash1 (absent, small, or homeotic)-like (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116539
Encoded Proteins
IDBP-103262
ash1 (absent, small, or homeotic)-like (Drosophila)
IDBP-245727
ash1 (absent, small, or homeotic)-like (Drosophila)
IDBP-602101
ash1 (absent, small, or homeotic)-like (Drosophila)
IDBP-596953
ash1 (absent, small, or homeotic)-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155335268-155562807
Strand Reverse strand
Band q22
Transcripts
ENST00000368346 ENSP00000357330
ENST00000392403 ENSP00000376204
ENST00000478837
ENST00000492987 ENSP00000448820
ENST00000477427
ENST00000548566
ENST00000548830 ENSP00000449283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0006323 DNA packaging
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0034968 histone lysine methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005923 tight junction
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028053
View Gene Order
ENSBTAG00000003954
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VWK7
UniProt Splice Variant
Entrez Gene 55870
UniGene Hs.491060 Hs.703340
RefSeq NM_018489 XM_005245336 XM_005245337 XM_006711450 XM_006711451
HUGO HGNC:19088
OMIM 607999
CCDS CCDS1113
HPRD 06416
IMGT
EMBL AL139410 AL353807
GenPept
RNA Seq Atlas 55870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca