InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASH1L

Summary

InnateDB Protein

IDBP-245727.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASH1L

Protein Name

ash1 (absent, small, or homeotic)-like (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376204

InnateDB Gene

IDBG-103260 (ASH1L)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me). {ECO:0000269PubMed:21239497}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10860993}. Cell junction, tight junction {ECO:0000269PubMed:10860993}. Chromosome {ECO:0000305PubMed:10860993}. Note=The relevance of tight junction localization is however unclear.

Disease Associations

Tissue Specificity

Widely expressed, with highest level in brain, heart and kidney. {ECO:0000269PubMed:10860993}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0006323	DNA packaging
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0034968	histone lysine methylation

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005923	tight junction
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001025 Bromo adjacent homology (BAH) domain
IPR001214 SET domain
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR003616 Post-SET domain
IPR006560 AWS domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017956 AT hook, DNA-binding motif
IPR019787 Zinc finger, PHD-finger

PFAM

PF01426
PF00856
PF00439
PF02178
PF00628

PRINTS

PR00503

PIRSF

SMART