Version 5.4
Homo sapiens Gene: MNDA
Summary
InnateDB Gene IDBG-103838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MNDA
Gene Name myeloid cell nuclear differentiation antigen
Synonyms PYHIN3
Species Homo sapiens
Ensembl Gene ENSG00000163563
Encoded Proteins
IDBP-103840
myeloid cell nuclear differentiation antigen
IDBP-389186
myeloid cell nuclear differentiation antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:158831317-158849506
Strand Forward strand
Band q23.1
Transcripts
ENST00000368141 ENSP00000357123
ENST00000438394 ENSP00000406800
ENST00000491210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006968 cellular defense response
GO:0006974 cellular response to DNA damage stimulus
GO:0030889 negative regulation of B cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P41218
TrEMBL Q5VUU6
UniProt Splice Variant
Entrez Gene 4332
UniGene Hs.153837
RefSeq NM_002432
HUGO HGNC:7183
OMIM 159553
CCDS CCDS1177
HPRD 15932
IMGT
EMBL AK290392 BC032319 CH471121 M81750
GenPept AAA69696 AAH32319 BAF83081 EAW52807
RNA Seq Atlas 4332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca