InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MNDA

Summary

InnateDB Protein

IDBP-103840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MNDA

Protein Name

myeloid cell nuclear differentiation antigen

Synonyms

PYHIN3;

Species

Homo sapiens

Ensembl Protein

ENSP00000357123

InnateDB Gene

IDBG-103838 (MNDA)

Protein Structure

UniProt Annotation

Function

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Subcellular Localization

Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Disease Associations

Tissue Specificity

Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia. {ECO:0000269PubMed:8175894}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006968	cellular defense response
GO:0006974	cellular response to DNA damage stimulus
GO:0030889	negative regulation of B cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0050853	B cell receptor signaling pathway