Version 5.4
Homo sapiens Gene: IGSF8
Summary
InnateDB Gene IDBG-103984.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGSF8
Gene Name immunoglobulin superfamily, member 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162729
Encoded Proteins
IDBP-103986
immunoglobulin superfamily, member 8
IDBP-103988
immunoglobulin superfamily, member 8
IDBP-389221
immunoglobulin superfamily, member 8
IDBP-810862
immunoglobulin superfamily, member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160091340-160098943
Strand Reverse strand
Band q23.2
Transcripts
ENST00000368086 ENSP00000357065
ENST00000314485 ENSP00000316664
ENST00000448417 ENSP00000397464
ENST00000460351
ENST00000614243 ENSP00000477565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 167 [view]
Protein-Protein 165 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0007338 single fertilization
GO:0007399 nervous system development
GO:0007519 skeletal muscle tissue development
GO:0008283 cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038034
View Gene Order
ENSBTAG00000009982
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.332012 Hs.733654 Hs.736834
RefSeq NM_001206665 NM_052868 XM_005245614 XM_006711631
HUGO
OMIM
CCDS CCDS1195
HPRD 09438
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca