Version 5.4
Homo sapiens Protein: IGSF8
Summary
InnateDB Protein IDBP-103988.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGSF8
Protein Name immunoglobulin superfamily, member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000316664
InnateDB Gene IDBG-103984 (IGSF8)
Protein Structure
UniProt Annotation
Function May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. {ECO:0000269PubMed:11504738, ECO:0000269PubMed:12750295, ECO:0000269PubMed:12752121, ECO:0000269PubMed:14662754, ECO:0000269PubMed:15070678}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets. {ECO:0000269PubMed:11504738, ECO:0000269PubMed:12708969, ECO:0000269PubMed:12750295}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 167 [view]
Protein-Protein 165 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0007338 single fertilization
GO:0007399 nervous system development
GO:0007519 skeletal muscle tissue development
GO:0008283 cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969P0
PhosphoSite PhosphoSite-Q969P0
TrEMBL C9J8Z4
UniProt Splice Variant
Entrez Gene 93185
UniGene Hs.736834
RefSeq NP_443100
HUGO HGNC:17813
OMIM 606644
CCDS CCDS1195
HPRD 09438
IMGT
EMBL AF311906 AF407274 AK055843 AL121987 AY044845 AY157579 BC004108 BC053881
GenPept AAH04108 AAH53881 AAK92220 AAL01052 AAM94901 AAO13163 BAB71027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca