Version 5.4
Homo sapiens Gene: NHLH1
Summary
InnateDB Gene IDBG-104045.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NHLH1
Gene Name nescient helix loop helix 1
Synonyms bHLHa35; HEN1; NSCL; NSCL1
Species Homo sapiens
Ensembl Gene ENSG00000171786
Encoded Proteins
IDBP-104047
nescient helix loop helix 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160367067-160372848
Strand Forward strand
Band q23.2
Transcripts
ENST00000302101 ENSP00000302189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007417 central nervous system development
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051251
View Gene Order
ENSBTAG00000020027
Not yet available
Cross-References
SwissProt Q02575
TrEMBL Q5T203
UniProt Splice Variant
Entrez Gene 4807
UniGene Hs.30956 Hs.606464
RefSeq NM_005598
HUGO HGNC:7817
OMIM 162360
CCDS CCDS1204
HPRD
IMGT
EMBL AK313700 BC013789 BT006859 CH471121 M97507
GenPept AAA58634 AAH13789 AAP35505 BAG36446 EAW52719
RNA Seq Atlas 4807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca