Version 5.4
Homo sapiens Gene: CD84
Summary
InnateDB Gene IDBG-104060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD84
Gene Name CD84 molecule
Synonyms hCD84; LY9B; mCD84; SLAMF5
Species Homo sapiens
Ensembl Gene ENSG00000066294
Encoded Proteins
IDBP-104062
CD84 molecule
IDBP-104066
CD84 molecule
IDBP-104068
CD84 molecule
IDBP-104070
CD84 molecule
IDBP-587245
CD84 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160541095-160579516
Strand Reverse strand
Band q23.3
Transcripts
ENST00000368054 ENSP00000357033
ENST00000360056
ENST00000311224 ENSP00000312367
ENST00000368051 ENSP00000357030
ENST00000368048 ENSP00000357027
ENST00000368047
ENST00000466767
ENST00000534968 ENSP00000442845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007156 homophilic cell adhesion
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038147
View Gene Order
ENSBTAG00000019033
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.398093 Hs.610260
RefSeq NM_001184879 NM_001184881 NM_001184882 NM_003874
HUGO
OMIM
CCDS CCDS1206 CCDS53395 CCDS53396 CCDS53397
HPRD 05151
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca