Version 5.4
Homo sapiens Protein: CD84
Summary
InnateDB Protein IDBP-104062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD84
Protein Name CD84 molecule
Synonyms hCD84; LY9B; mCD84; SLAMF5;
Species Homo sapiens
Ensembl Protein ENSP00000357033
InnateDB Gene IDBG-104060 (CD84)
Protein Structure
UniProt Annotation
Function Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. {ECO:0000269PubMed:11564780, ECO:0000269PubMed:12115647, ECO:0000269PubMed:12928397, ECO:0000269PubMed:12962726, ECO:0000269PubMed:16037392}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11389028, ECO:0000269PubMed:12962726}; Single-pass type I membrane protein {ECO:0000269PubMed:11389028, ECO:0000269PubMed:12962726}.
Disease Associations
Tissue Specificity Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. {ECO:0000269PubMed:10698700, ECO:0000269PubMed:11564780, ECO:0000269PubMed:12115647, ECO:0000269PubMed:12962726, ECO:0000269PubMed:15245368, ECO:0000269PubMed:9310491}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007156 homophilic cell adhesion
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIB8
PhosphoSite PhosphoSite-Q9UIB8
TrEMBL
UniProt Splice Variant
Entrez Gene 8832
UniGene Hs.610260
RefSeq NP_003865
HUGO HGNC:1704
OMIM 604513
CCDS CCDS1206
HPRD 05151
IMGT
EMBL AF054815 AF054816 AF054817 AF054818 AF081189 AH008376 AH008972 AJ223324 AK296290 AK313496 AL138930 BC020063 CH471121 CR541847 CR933666 U82988 U96627 Y12632
GenPept AAB84364 AAD04232 AAD13155 AAF06840 AAF21721 AAF21722 AAF21723 AAF21724 AAF21784 AAH20063 BAG36278 BAH12304 CAA11264 CAA73181 CAG46645 CAI15158 CAI15159 CAI15160 CAI15161 CAI15162 CAI15163 CAI45963 EAW52707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca