InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: B4GALT3

Summary

InnateDB Gene

IDBG-104210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B4GALT3

Gene Name

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

Synonyms

beta4Gal-T3

Species

Homo sapiens

Ensembl Gene

ENSG00000158850

Encoded Proteins

IDBP-104212

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

IDBP-104218

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

IDBP-812933

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:161171310-161177968

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000319769	ENSP00000320965
ENST00000367998	ENSP00000356977
ENST00000470882
ENST00000486938
ENST00000466504
ENST00000465740
ENST00000493164
ENST00000496313
ENST00000487004
ENST00000482288
ENST00000460415
ENST00000467863
ENST00000622395	ENSP00000480428

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003945	N-acetyllactosamine synthase activity
GO:0008378	galactosyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome