Version 5.4
| Bos taurus Gene: B4GALT3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||
| InnateDB Gene | IDBG-630172.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | B4GALT3 | ||||||||||||
| Gene Name | Beta-1,4-galactosyltransferase 3 N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000021897 | ||||||||||||
| Encoded Proteins |
beta-1,4-galactosyltransferase 3
|
||||||||||||
| Protein Structure |
|
||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158850:
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010] |
||||||||||||
| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 3:8340547-8345532 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
|
||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
|
||||||||||||
| Gene Ontology | |||||||||||||
Molecular Function |
|
||||||||||||
| Biological Process |
|
||||||||||||
| Cellular Component |
|
||||||||||||
| Orthologs | |||||||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||
| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Defective EXT2 causes exostoses 2 pathway
Defective CHST6 causes MCDC1 pathway
MPS IIIA - Sanfilippo syndrome A pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
N-Glycan antennae elongation pathway
Glycosaminoglycan metabolism pathway
Defective CHSY1 causes TPBS pathway
MPS I - Hurler syndrome pathway
MPS IIID - Sanfilippo syndrome D pathway
Diseases associated with glycosaminoglycan metabolism pathway
Transport to the Golgi and subsequent modification pathway
MPS IX - Natowicz syndrome pathway
Myoclonic epilepsy of Lafora pathway
MPS II - Hunter syndrome pathway
MPS VII - Sly syndrome pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Defective B3GAT3 causes JDSSDHD pathway
Asparagine N-linked glycosylation pathway
Mucopolysaccharidoses pathway
Diseases of glycosylation pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
MPS IIIC - Sanfilippo syndrome C pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Defective CHST3 causes SEDCJD pathway
Metabolism pathway
Keratan sulfate biosynthesis pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective SLC26A2 causes chondrodysplasias pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome A pathway
MPS IV - Morquio syndrome B pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Disease pathway
Keratan sulfate/keratin metabolism pathway
|
||||||||||||
| KEGG | |||||||||||||
| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
N-Glycan antennae elongation pathway
Transport to the Golgi and subsequent modification pathway
Asparagine N-linked glycosylation pathway
Keratan sulfate biosynthesis pathway
Mucopolysaccharidoses pathway
Post-translational protein modification pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
Keratan sulfate/keratin metabolism pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Metabolism of proteins pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Glycosaminoglycan metabolism pathway
Keratan sulfate biosynthesis pathway
Disease pathway
N-Glycan antennae elongation pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Transport to the Golgi and subsequent modification pathway
MPS IV - Morquio syndrome B pathway
MPS IV - Morquio syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
Metabolism of proteins pathway
MPS IIID - Sanfilippo syndrome D pathway
Post-translational protein modification pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Diseases of glycosylation pathway
Defective CHSY1 causes TPBS pathway
Defective B3GAT3 causes JDSSDHD pathway
MPS II - Hunter syndrome pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS IX - Natowicz syndrome pathway
Glycogen storage diseases pathway
MPS VII - Sly syndrome pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Defective CHST3 causes SEDCJD pathway
Asparagine N-linked glycosylation pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Keratan sulfate/keratin metabolism pathway
MPS IIIB - Sanfilippo syndrome B pathway
MPS IIIA - Sanfilippo syndrome A pathway
Defective PAPSS2 causes SEMD-PA pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Mucopolysaccharidoses pathway
Defective CHST6 causes MCDC1 pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Defective EXT2 causes exostoses 2 pathway
Defective SLC26A2 causes chondrodysplasias pathway
|
||||||||||||
| KEGG |
N-Glycan biosynthesis pathway
Glycosphingolipid biosynthesis pathway
Glycosaminoglycan biosynthesis pathway
Other types of O-glycan biosynthesis pathway
N-Glycan biosynthesis pathway
Glycosphingolipid biosynthesis pathway
Glycosaminoglycan biosynthesis pathway
Other types of O-glycan biosynthesis pathway
|
||||||||||||
| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q5EA87 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 515771 | ||||||||||||
| UniGene | Bt.4375 | ||||||||||||
| RefSeq | NM_001015609 XM_005203501 XM_005203502 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC123718 BT020682 BT020868 BT020916 BT026158 | ||||||||||||
| GenPept | AAI23719 AAX08699 AAX08885 AAX08933 ABG66997 | ||||||||||||
| RNA Seq Atlas | 515771 | ||||||||||||