Version 5.4
Homo sapiens Gene: SH2D1B
Summary
InnateDB Gene IDBG-104379.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D1B
Gene Name SH2 domain containing 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198574
Encoded Proteins
IDBP-104381
SH2 domain containing 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:162395266-162412138
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367929 ENSP00000356906
ENST00000493550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030674 protein binding, bridging
Biological Process
GO:0002366 leukocyte activation involved in immune response
GO:0002717 positive regulation of natural killer cell mediated immunity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032814 regulation of natural killer cell activation
GO:0045089 positive regulation of innate immune response
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005622 intracellular
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt O14796
TrEMBL
UniProt Splice Variant
Entrez Gene 117157
UniGene Hs.350581
RefSeq NM_053282
HUGO HGNC:30416
OMIM 608510
CCDS CCDS30928
HPRD
IMGT
EMBL AF020264 AF256653 AF403479 AF484964 AK097162 AK314743 AL512785 BC022407 BC066595 CH471067
GenPept AAB70927 AAH22407 AAH66595 AAL26000 AAL27357 AAM28522 BAC04968 BAG37283 CAI15780 EAW90703
RNA Seq Atlas 117157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca