InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH2D1B

Summary

InnateDB Protein

IDBP-104381.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2D1B

Protein Name

SH2 domain containing 1B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356906

InnateDB Gene

IDBG-104379 (SH2D1B)

Protein Structure

UniProt Annotation

Function

Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030674	protein binding, bridging

Biological Process

GO:0002366	leukocyte activation involved in immune response
GO:0002717	positive regulation of natural killer cell mediated immunity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032814	regulation of natural killer cell activation
GO:0045089	positive regulation of innate immune response
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation