Version 5.4
Homo sapiens Gene: UHMK1
Summary
InnateDB Gene IDBG-104384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UHMK1
Gene Name U2AF homology motif (UHM) kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152332
Encoded Proteins
IDBP-485561
U2AF homology motif (UHM) kinase 1
IDBP-593465
U2AF homology motif (UHM) kinase 1
IDBP-583718
U2AF homology motif (UHM) kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:162497251-162529629
Strand Forward strand
Band q23.3
Transcripts
ENST00000282169
ENST00000489294 ENSP00000420270
ENST00000545294 ENSP00000441226
ENST00000538489 ENSP00000446416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0018105 peptidyl-serine phosphorylation
GO:0031175 neuron projection development
GO:0045948 positive regulation of translational initiation
GO:0046777 protein autophosphorylation
GO:0046825 regulation of protein export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0032839 dendrite cytoplasm
GO:0071598 neuronal ribonucleoprotein granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026667
View Gene Order
ENSBTAG00000012694
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.127310 Hs.601000 Hs.708149 Hs.713167
RefSeq NM_001184763 NM_144624 NM_175866
HUGO
OMIM
CCDS CCDS1239 CCDS53423 CCDS53424
HPRD 12318
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca