InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDR2

Summary

InnateDB Gene

IDBG-104396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDR2

Gene Name

discoidin domain receptor tyrosine kinase 2

Synonyms

MIG20a; NTRKR3; TKT; TYRO10

Species

Homo sapiens

Ensembl Gene

ENSG00000162733

Encoded Proteins

IDBP-104398

discoidin domain receptor tyrosine kinase 2

IDBP-104400

discoidin domain receptor tyrosine kinase 2

IDBP-389432

discoidin domain receptor tyrosine kinase 2

IDBP-389433

discoidin domain receptor tyrosine kinase 2

IDBP-389434

discoidin domain receptor tyrosine kinase 2

IDBP-389435

discoidin domain receptor tyrosine kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5\' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:162631373-162787400

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000367922	ENSP00000356899
ENST00000367921	ENSP00000356898
ENST00000446985	ENSP00000400309
ENST00000415555	ENSP00000391310
ENST00000458105	ENSP00000417030
ENST00000433757	ENSP00000396864

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0038062	protein tyrosine kinase collagen receptor activity

Biological Process

GO:0001503	ossification
GO:0003416	endochondral bone growth
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010715	regulation of extracellular matrix disassembly
GO:0010763	positive regulation of fibroblast migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030500	regulation of bone mineralization
GO:0031214	biomineral tissue development
GO:0035988	chondrocyte proliferation
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
GO:0045669	positive regulation of osteoblast differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046777	protein autophosphorylation
GO:0048146	positive regulation of fibroblast proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0090091	positive regulation of extracellular matrix disassembly

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026674

View Gene Order

ENSBTAG00000004885

Not yet available

Pathways

NETPATH

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_163874

Non-integrin membrane-ECM interactions pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.593833

RefSeq

NM_001014796 NM_006182 XM_005245221 XM_006711344

HUGO

OMIM

CCDS

CCDS1241

HPRD

01868

IMGT

EMBL

GenPept

RNA Seq Atlas