Version 5.4
Homo sapiens Gene: SELP
Summary
InnateDB Gene IDBG-104675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELP
Gene Name selectin P (granule membrane protein 140kDa, antigen CD62)
Synonyms CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM; PSEL
Species Homo sapiens
Ensembl Gene ENSG00000174175
Encoded Proteins
IDBP-104677
selectin P (granule membrane protein 140kDa, antigen CD62)
IDBP-104679
selectin P (granule membrane protein 140kDa, antigen CD62)
IDBP-104693
selectin P (granule membrane protein 140kDa, antigen CD62)
IDBP-104695
selectin P (granule membrane protein 140kDa, antigen CD62)
IDBP-389573
selectin P (granule membrane protein 140kDa, antigen CD62)
IDBP-389574
selectin P (granule membrane protein 140kDa, antigen CD62)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169588849-169630193
Strand Reverse strand
Band q24.2
Transcripts
ENST00000367795 ENSP00000356769
ENST00000263686 ENSP00000263686
ENST00000367788 ENSP00000356762
ENST00000367786 ENSP00000356760
ENST00000426706 ENSP00000391694
ENST00000458599 ENSP00000399368
ENST00000466167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
GO:0033691 sialic acid binding
GO:0042806 fucose binding
GO:0043208 glycosphingolipid binding
GO:0048306 calcium-dependent protein binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007596 blood coagulation
GO:0010572 positive regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0032496 response to lipopolysaccharide
GO:0033623 regulation of integrin activation
GO:0050829 defense response to Gram-negative bacterium
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031088 platelet dense granule membrane
GO:0031092 platelet alpha granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026580
View Gene Order
ENSBTAG00000020755
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05144
Malaria pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL Q5R349 Q6ULR6
UniProt Splice Variant
Entrez Gene 6403
UniGene Hs.73800
RefSeq XM_005245438 NM_003005 XM_005245435 XM_005245436 XM_005245440
HUGO HGNC:10721
OMIM 173610
CCDS CCDS1282
HPRD 01433
IMGT
EMBL AL022146 AY367063 Z99572
GenPept AAQ67703
RNA Seq Atlas 6403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca