InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Selp

Summary

InnateDB Gene

IDBG-202346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Selp

Gene Name

selectin, platelet

Synonyms

CD62P; GMP-140; Grmp; LECAM3; PADGEM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026580

Encoded Proteins

IDBP-539214

selectin, platelet

IDBP-535101

selectin, platelet

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174175:
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:164115264-164150026

Strand

Forward strand

Band

H2.2

Transcripts

ENSMUST00000162746	ENSMUSP00000123924
ENSMUST00000160000
ENSMUST00000161152	ENSMUSP00000124231
ENSMUST00000161020
ENSMUST00000162102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0030246	carbohydrate binding
GO:0033691	sialic acid binding
GO:0042806	fucose binding
GO:0048306	calcium-dependent protein binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0010572	positive regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0033623	regulation of integrin activation
GO:0050900	leukocyte migration
GO:0050901	leukocyte tethering or rolling
GO:0071354	cellular response to interleukin-6

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031092	platelet alpha granule membrane