Version 5.4
Homo sapiens Gene: SELL
Summary
InnateDB Gene IDBG-104696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELL
Gene Name selectin L
Synonyms CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; TQ1
Species Homo sapiens
Ensembl Gene ENSG00000188404
Encoded Proteins
IDBP-104698
selectin L
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169690667-169711698
Strand Reverse strand
Band q24.2
Transcripts
ENST00000236147 ENSP00000236147
ENST00000497295
ENST00000463108
ENST00000460650
ENST00000479657
ENST00000466340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
GO:0043208 glycosphingolipid binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0033198 response to ATP
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026581
View Gene Order
ENSBTAG00000011515
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.728756
RefSeq NM_000655
HUGO
OMIM
CCDS CCDS53427
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca