Version 5.4
Bos taurus Gene: SELL
Summary
InnateDB Gene IDBG-631879.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELL
Gene Name L-selectin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011515
Encoded Proteins
IDBP-683452
L-selectin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188404:
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:38158186-38173226
Strand Reverse strand
Band
Transcripts
ENSBTAT00000046865 ENSBTAP00000044113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0033198 response to ATP
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000188404
View Gene Order
ENSMUSG00000026581
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N4U9
UniProt Splice Variant
Entrez Gene 281485
UniGene Bt.2314
RefSeq NM_174182 XM_005216880 XM_005216881
HUGO HGNC:10720
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02042854
GenPept
RNA Seq Atlas 281485

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca