Version 5.4
Homo sapiens Gene: MYOC
Summary
InnateDB Gene IDBG-104799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOC
Gene Name myocilin, trabecular meshwork inducible glucocorticoid response
Synonyms GLC1A; GPOA; JOAG; JOAG1; myocilin; TIGR
Species Homo sapiens
Ensembl Gene ENSG00000034971
Encoded Proteins
IDBP-104801
myocilin, trabecular meshwork inducible glucocorticoid response
IDBP-808471
myocilin, trabecular meshwork inducible glucocorticoid response
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171635417-171652683
Strand Reverse strand
Band q24.3
Transcripts
ENST00000037502 ENSP00000037502
ENST00000614688 ENSP00000478680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0032027 myosin light chain binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014734 skeletal muscle hypertrophy
GO:0022011 myelination in peripheral nervous system
GO:0030335 positive regulation of cell migration
GO:0031175 neuron projection development
GO:0035024 negative regulation of Rho protein signal transduction
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0038133 ERBB2-ERBB3 signaling pathway
GO:0043408 regulation of MAPK cascade
GO:0045162 clustering of voltage-gated sodium channels
GO:0051496 positive regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060348 bone development
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005929 cilium
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031012 extracellular matrix
GO:0031410 cytoplasmic vesicle
GO:0033268 node of Ranvier
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026697
View Gene Order
ENSBTAG00000020342
Not yet available
Cross-References
SwissProt Q99972
TrEMBL B4DV60
UniProt Splice Variant
Entrez Gene 4653
UniGene Hs.436037
RefSeq NM_000261
HUGO HGNC:7610
OMIM 601652
CCDS CCDS1297
HPRD 03387
IMGT
EMBL AB006688 AF001620 AF049791 AF049792 AF049793 AK300943 AK315443 BC029261 CH471067 D88214 U85257 Z97171 Z97174 Z97177 Z98750
GenPept AAC14264 AAC51725 AAC52051 AAH29261 BAA23531 BAA24532 BAG37831 BAG62572 CAB09899 CAD92590 EAW90903
RNA Seq Atlas 4653

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca