Version 5.4
Bos taurus Gene: MYOC
Summary
InnateDB Gene IDBG-632216.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOC
Gene Name myocilin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020342
Encoded Proteins
IDBP-683817
myocilin precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000034971:
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:39957137-39971282
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027111 ENSBTAP00000027111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0032027 myosin light chain binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014734 skeletal muscle hypertrophy
GO:0022011 myelination in peripheral nervous system
GO:0030335 positive regulation of cell migration
GO:0031175 neuron projection development
GO:0035024 negative regulation of Rho protein signal transduction
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0038133 ERBB2-ERBB3 signaling pathway
GO:0043408 regulation of MAPK cascade
GO:0045162 clustering of voltage-gated sodium channels
GO:0051496 positive regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060348 bone development
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005615 extracellular space
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0031012 extracellular matrix
GO:0031410 cytoplasmic vesicle
GO:0033268 node of Ranvier
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000034971
View Gene Order
ENSMUSG00000026697
View Gene Order
Cross-References
SwissProt
TrEMBL Q3SX06
UniProt Splice Variant
Entrez Gene 281342
UniGene Bt.4703
RefSeq NM_174118
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104571 DAAA02042884
GenPept AAI04572
RNA Seq Atlas 281342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca