Version 5.4
Homo sapiens Gene: CCNF
Summary
InnateDB Gene IDBG-10480.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNF
Gene Name cyclin F
Synonyms FBX1; FBXO1
Species Homo sapiens
Ensembl Gene ENSG00000162063
Encoded Proteins
IDBP-10482
cyclin F
IDBP-236171
cyclin F
IDBP-749462
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2429394-2458854
Strand Forward strand
Band p13.3
Transcripts
ENST00000293968 ENSP00000293968
ENST00000397066 ENSP00000380256
ENST00000569093
ENST00000564236 ENSP00000457587
ENST00000564333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000320 re-entry into mitotic cell cycle
GO:0001890 placenta development
GO:0007067 mitotic nuclear division
GO:0010826 negative regulation of centrosome duplication
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005814 centriole
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000072082
View Gene Order
ENSBTAG00000006591
Not yet available
Cross-References
SwissProt P41002
TrEMBL H0Y2P7
UniProt Splice Variant
Entrez Gene 899
UniGene Hs.1973
RefSeq NM_001761
HUGO HGNC:1591
OMIM 600227
CCDS CCDS10467
HPRD
IMGT
EMBL AC106820 AK313371 BC012349 U17105 Z36714
GenPept AAB60342 AAH12349 BAG36170 CAA85308
RNA Seq Atlas 899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca