Version 5.4
Mus musculus Gene: Ccnf
Summary
InnateDB Gene IDBG-145650.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccnf
Gene Name cyclin F
Synonyms CycF; Fbxo1
Species Mus musculus
Ensembl Gene ENSMUSG00000072082
Encoded Proteins
IDBP-249744
cyclin F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162063:
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24223232-24251409
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000115390 ENSMUSP00000111048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000320 re-entry into mitotic cell cycle
GO:0001890 placenta development
GO:0007067 mitotic nuclear division
GO:0010826 negative regulation of centrosome duplication
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005814 centriole
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162063
View Gene Order
ENSBTAG00000006591
Not yet available
Cross-References
SwissProt P51944
TrEMBL
UniProt Splice Variant
Entrez Gene 12449
UniGene Mm.413472 Mm.77695
RefSeq NM_007634 XM_006523554
OMIM
CCDS CCDS37484
HPRD
IMGT
MGI ID MGI:102551
MGI Symbol Ccnf
EMBL AC117577 AK030298 AK082485 AK159594 AK169263 BC037662 U20612 U20636 Z47766
GenPept AAA62317 AAA63152 AAH37662 BAC26886 BAC38507 BAE35214 BAE41025 CAA87695
RNA Seq Atlas 12449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca