Version 5.4
Homo sapiens Gene: CACYBP
Summary
InnateDB Gene IDBG-104961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACYBP
Gene Name calcyclin binding protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116161
Encoded Proteins
IDBP-104965
calcyclin binding protein
IDBP-292976
calcyclin binding protein
IDBP-292977
calcyclin binding protein
IDBP-389715
calcyclin binding protein
IDBP-810766
calcyclin binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:174999163-175011715
Strand Forward strand
Band q25.1
Transcripts
ENST00000367679 ENSP00000356652
ENST00000406752 ENSP00000384139
ENST00000405362 ENSP00000385771
ENST00000426793 ENSP00000403674
ENST00000461977
ENST00000483307
ENST00000473925
ENST00000469173
ENST00000613570 ENSP00000479414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 102 [view]
Protein-Protein 98 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007507 heart development
GO:0007568 aging
GO:0045740 positive regulation of DNA replication
GO:0055007 cardiac muscle cell differentiation
GO:0060416 response to growth hormone
GO:0060548 negative regulation of cell death
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0030877 beta-catenin destruction complex
GO:0043005 neuron projection
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014226
View Gene Order
ENSBTAG00000001107
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.508524 Hs.614328
RefSeq NM_001007214 NM_014412
HUGO
OMIM
CCDS CCDS1315 CCDS30942
HPRD 07316
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca