Version 5.4
Mus musculus Gene: Cacybp
Summary
InnateDB Gene IDBG-201111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacybp
Gene Name calcyclin binding protein
Synonyms SIP
Species Mus musculus
Ensembl Gene ENSMUSG00000014226
Encoded Proteins
IDBP-201113
calcyclin binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116161:
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160202367-160212892
Strand Reverse strand
Band H2.1
Transcripts
ENSMUST00000014370 ENSMUSP00000014370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007507 heart development
GO:0007568 aging
GO:0045740 positive regulation of DNA replication
GO:0055007 cardiac muscle cell differentiation
GO:0060416 response to growth hormone
GO:0060548 negative regulation of cell death
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0030877 beta-catenin destruction complex
GO:0043005 neuron projection
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116161
View Gene Order
ENSBTAG00000001107
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9CXW3
TrEMBL
UniProt Splice Variant
Entrez Gene 12301
UniGene Mm.10702 Mm.403910
RefSeq NM_009786
OMIM
CCDS CCDS15406
HPRD
IMGT
MGI ID MGI:1270839
MGI Symbol Cacybp
EMBL AK013924 BC025948 U97327
GenPept AAC16757 AAH25948
RNA Seq Atlas 12301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca