Version 5.4
Homo sapiens Gene: RASAL2
Summary
InnateDB Gene IDBG-105036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASAL2
Gene Name RAS protein activator like 2
Synonyms NGAP
Species Homo sapiens
Ensembl Gene ENSG00000075391
Encoded Proteins
IDBP-105040
RAS protein activator like 2
IDBP-389757
RAS protein activator like 2
IDBP-478636
RAS protein activator like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:178094141-178484147
Strand Forward strand
Band q25.2
Transcripts
ENST00000367649 ENSP00000356621
ENST00000433130 ENSP00000402897
ENST00000465723
ENST00000462775 ENSP00000420558
ENST00000463079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0042325 regulation of phosphorylation
GO:0046580 negative regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070565
View Gene Order
ENSBTAG00000015537
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496139 Hs.726848
RefSeq NM_004841 NM_170692 XM_006711634
HUGO
OMIM
CCDS CCDS1321 CCDS1322
HPRD 05845
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca