InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASAL2

Summary

InnateDB Protein

IDBP-478636.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASAL2

Protein Name

RAS protein activator like 2

Synonyms

NGAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000420558

InnateDB Gene

IDBG-105036 (RASAL2)

Protein Structure

UniProt Annotation

Function

Inhibitory regulator of the Ras-cyclic AMP pathway.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0042325	regulation of phosphorylation
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008025 PKC-activated phosphatase-1 inhibitor
IPR008936 Rho GTPase activation protein
IPR021887 Protein of unknown function DUF3498

PFAM

PF00168
PF00169
PF00616
PF05361
PF12004

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt