Version 5.4
Homo sapiens Gene: ABL2
Summary
InnateDB Gene IDBG-105099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABL2
Gene Name v-abl Abelson murine leukemia viral oncogene homolog 2
Synonyms ABLL; ARG
Species Homo sapiens
Ensembl Gene ENSG00000143322
Encoded Proteins
IDBP-105101
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-105103
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-246463
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-484066
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-483588
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-473370
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-475341
v-abl Abelson murine leukemia viral oncogene homolog 2
IDBP-474998
v-abl Abelson murine leukemia viral oncogene homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:179099327-179229684
Strand Reverse strand
Band q25.2
Transcripts
ENST00000344730 ENSP00000339209
ENST00000367623 ENSP00000356595
ENST00000392043 ENSP00000375897
ENST00000502732 ENSP00000427562
ENST00000512653 ENSP00000423578
ENST00000504405 ENSP00000426831
ENST00000507173 ENSP00000423413
ENST00000511413 ENSP00000424697
ENST00000509520
ENST00000504324
ENST00000508127
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 48 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003785 actin monomer binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030145 manganese ion binding
GO:0051015 actin filament binding
Biological Process
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0010506 regulation of autophagy
GO:0010976 positive regulation of neuron projection development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030100 regulation of endocytosis
GO:0030155 regulation of cell adhesion
GO:0051017 actin filament bundle assembly
GO:0051353 positive regulation of oxidoreductase activity
GO:0071300 cellular response to retinoic acid
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026596
View Gene Order
ENSBTAG00000015026
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_19230
Role of Abl in Robo-Slit signaling pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa05416
Viral myocarditis pathway
INOH
PID NCI
Cross-References
SwissProt P42684
TrEMBL
UniProt Splice Variant
Entrez Gene 27
UniGene Hs.159472 Hs.614321 Hs.630545
RefSeq NM_005158 NM_001136000 NM_001136001 NM_001168236 NM_001168237 NM_001168238 NM_001168239 NM_007314 XM_005245088
HUGO HGNC:77
OMIM 164690
CCDS CCDS41441 CCDS30947 CCDS44282 CCDS44283 CCDS53435 CCDS53436 CCDS53437 CCDS53438
HPRD 01259
IMGT
EMBL AK311045 AL139132 AL359179 AL512326 BC065912 BX538317 CH471067 DQ009672 FJ542283 FJ542284 FJ542285 FJ542286 M35296
GenPept AAA35553 AAH65912 AAY16984 ACK76601 ACK76602 ACK76603 ACK76604 CAD98092 CAH70921 CAH70925 CAI13566 CAI13570 CAI15584 CAI15585 EAW91040
RNA Seq Atlas 27

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca