InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abl2

Summary

InnateDB Gene

IDBG-200390.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abl2

Gene Name

v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

Synonyms

AA536808; Abll; Arg

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026596

Encoded Proteins

IDBP-200392

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

IDBP-621077

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

IDBP-621087

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

IDBP-787987

v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143322:
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:156558786-156649568

Strand

Forward strand

Band

Transcripts

ENSMUST00000027888	ENSMUSP00000027888
ENSMUST00000173929	ENSMUSP00000133381
ENSMUST00000166172	ENSMUSP00000126181
ENSMUST00000190749	ENSMUSP00000140125

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030145	manganese ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007015	actin filament organization
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0051017	actin filament bundle assembly
GO:0051353	positive regulation of oxidoreductase activity
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0015629	actin cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143322

View Gene Order

ENSBTAG00000015026

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04012

ErbB signaling pathway pathway

mmu05416

Viral myocarditis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_19230

Role of Abl in Robo-Slit signaling pathway

REACT_19351

Signaling by Robo receptor pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04012

ErbB signaling pathway pathway

hsa05416

Viral myocarditis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001136104 NM_009595 XM_006496619 XM_006496620 XM_006496621 XM_006496622

OMIM

CCDS

CCDS15393 CCDS48404

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas