Version 5.4
Homo sapiens Gene: CACNA1E
Summary
InnateDB Gene IDBG-105210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNA1E
Gene Name calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms BII; CACH6; CACNL1A6; Cav2.3
Species Homo sapiens
Ensembl Gene ENSG00000198216
Encoded Proteins
IDBP-105212
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-105214
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-105216
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-105218
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-105220
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-105222
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-583163
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-806524
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-806535
calcium channel, voltage-dependent, R type, alpha 1E subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the \'high-voltage activated\' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:181413102-181808084
Strand Forward strand
Band q25.3
Transcripts
ENST00000367573 ENSP00000356545
ENST00000367570 ENSP00000356542
ENST00000360108 ENSP00000353222
ENST00000367567 ENSP00000356539
ENST00000357570 ENSP00000350183
ENST00000358338 ENSP00000351101
ENST00000524607 ENSP00000432038
ENST00000533229
ENST00000621791 ENSP00000481619
ENST00000621551 ENSP00000483914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0044281 small molecule metabolic process
GO:0050796 regulation of insulin secretion
GO:0051899 membrane depolarization
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004110
View Gene Order
ENSBTAG00000020887
Not yet available
Pathways
NETPATH
REACTOME
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_13685
Neuronal System pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437444 Hs.537770 Hs.611396 Hs.637070
RefSeq NM_000721 NM_001205293 NM_001205294
HUGO
OMIM
CCDS CCDS53443 CCDS55664 CCDS55665
HPRD 03006
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca