Version 5.4
Mus musculus Gene: Cacna1e
Summary
InnateDB Gene IDBG-199519.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1e
Gene Name calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms A430040I15; alpha1E; BII; Cach6; Cacnl1a6; Cav2.3; Cchra1
Species Mus musculus
Ensembl Gene ENSMUSG00000004110
Encoded Proteins
IDBP-199521
calcium channel, voltage-dependent, R type, alpha 1E subunit
IDBP-789509
calcium channel, voltage-dependent, R type, alpha 1E subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154390731-154884501
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000004214 ENSMUSP00000004214
ENSMUST00000187541 ENSMUSP00000140937
ENSMUST00000188384
ENSMUST00000188965
ENSMUST00000188321
ENSMUST00000186256
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0001662 behavioral fear response
GO:0002027 regulation of heart rate
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007626 locomotory behavior
GO:0008542 visual learning
GO:0019226 transmission of nerve impulse
GO:0019233 sensory perception of pain
GO:0030317 sperm motility
GO:0034765 regulation of ion transmembrane transport
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0050877 neurological system process
GO:0055085 transmembrane transport
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
GO:0090273 regulation of somatostatin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198216
View Gene Order
ENSBTAG00000020887
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04930
Type II diabetes mellitus pathway
mmu04020
Calcium signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_13685
Neuronal System pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QK20
UniProt Splice Variant
Entrez Gene 12290
UniGene Mm.267517 Mm.409140
RefSeq NM_009782 XM_006529099
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:106217
MGI Symbol Cacna1e
EMBL AC099707 AC101727 AC122040
GenPept
RNA Seq Atlas 12290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca