Homo sapiens Gene: SMG7 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-105301.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SMG7 | ||||||||||||||||||
Gene Name | smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) | ||||||||||||||||||
Synonyms | C1orf16; EST1C; SGA56M | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000116698 | ||||||||||||||||||
Encoded Proteins |
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:183472216-183598246 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q25.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Nonsense-Mediated Decay (NMD) pathway
Gene Expression pathway
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KEGG |
mRNA surveillance pathway pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_001174061 NM_173156 NM_201568 NM_201569 XM_006711674 XM_006711675 XM_006711676 XM_006711677 XM_006711678 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS1355 CCDS41445 CCDS53444 CCDS53445 | ||||||||||||||||||
HPRD | 10723 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||