Version 5.4
| Mus musculus Gene: Smg7 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-198701.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Smg7 | ||||||||||||
| Gene Name | Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) | ||||||||||||
| Synonyms | |||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Gene | ENSMUSG00000042772 | ||||||||||||
| Encoded Proteins |
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116698:
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 1:152836995-152902646 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | G3 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Gene Expression pathway
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| KEGG |
mRNA surveillance pathway pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Nonsense-Mediated Decay (NMD) pathway
Gene Expression pathway
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| KEGG |
mRNA surveillance pathway pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q5RJH6 | ||||||||||||
| TrEMBL | Q3UKQ9 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 226517 | ||||||||||||
| UniGene | Mm.270775 Mm.470782 | ||||||||||||
| RefSeq | NM_001005507 XM_006529453 NM_001160256 NM_001160257 XM_006529452 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS35740 CCDS48394 CCDS48395 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| MGI ID | MGI:2682334 | ||||||||||||
| MGI Symbol | Smg7 | ||||||||||||
| EMBL | AK129101 AK145908 BC082789 BC086651 | ||||||||||||
| GenPept | AAH82789 AAH86651 BAC97911 BAE26742 | ||||||||||||
| RNA Seq Atlas | 226517 | ||||||||||||