Homo sapiens Gene: PDC
Summary
InnateDB Gene IDBG-105423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDC
Gene Name phosducin
Synonyms MEKA; PHD; PhLOP; PhLP;
Species Homo sapiens
Ensembl Gene ENSG00000116703
Encoded Proteins
phosducin
phosducin
Protein Structure
Entrez Gene
Summary This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:186443566-186461122
Strand Reverse strand
Band q31.1
Transcripts
ENST00000391997 ENSP00000375855
ENST00000497198 ENSP00000422775
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Olfactory transduction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P20941
TrEMBL A0A024R982 Q52LP8
UniProt Splice Variant
Entrez Gene 5132
UniGene Hs.654381
RefSeq NM_002597 NM_022576
HUGO HGNC:8759
OMIM 171490
CCDS CCDS1370 CCDS41447
HPRD 01373
IMGT
EMBL AF076463 AF076464 AL596220 AL663036 BC093839 BC112134 CH471067 M33478 M38058 M38059 M60720
GenPept AAA35486 AAA36210 AAD43141 AAD43142 AAH93839 AAI12135 CAI13122 EAW91212 EAW91215
ImmGen PDC (murine)
RNA Seq Atlas 5132