Homo sapiens Gene: PDC

Summary
InnateDB Gene IDBG-105423.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PDC
Gene Name phosducin
Synonyms MEKA; PHD; PhLOP; PhLP
Species Homo sapiens
Ensembl Gene ENSG00000116703
Encoded Proteins
IDBP-105425 phosducin
IDBP-246558 phosducin
IDBP-389818 phosducin
IDBP-482587 phosducin
Entrez Gene
Summary This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 186412698-186430254
Strand Reverse strand
Band q31.1
Transcripts
ENST00000340129  ENSP00000342033
ENST00000391997  ENSP00000375855
ENST00000456239  ENSP00000411564
ENST00000497198  ENSP00000422775
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein‑Protein  3
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004859 phospholipase inhibitor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000006007 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000004176 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa04740  Olfactory transduction
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P20941 
TrEMBL Q52LP8 Q9UP23
UniProt Splice Variant
Entrez Gene 5132 
UniGene Hs.654381
RefSeq NM_002597  NM_022576 
HUGO 8759 
OMIM 171490
CCDS CCDS1370  CCDS41447 
HPRD 01373
IMGT
EMBL AF076463 AF076464 AL596220 AL663036 BC093839 BC112134 CH471067 M33478 M38058 M38059 M60720
GenPept AAA35486  AAA36210  AAD43141  AAD43142  AAH93839  AAI12135  CAI13122  EAW91212 
ImmGen PDC (murine) 
RNA Seq Atlas 5132