InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDC

Summary

InnateDB Protein

IDBP-246558.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDC

Protein Name

phosducin

Synonyms

MEKA; PHD; PhLOP; PhLP;

Species

Homo sapiens

Ensembl Protein

ENSP00000375855

InnateDB Gene

IDBG-105423 (PDC)

Protein Structure

UniProt Annotation

Function

May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. {ECO:0000269PubMed:10866677}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:10866677}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269PubMed:10866677}. Photoreceptor inner segment {ECO:0000269PubMed:10866677}. Nucleus {ECO:0000269PubMed:10866677}. Note=Outer and inner segments of the rod cells.Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0043086	negative regulation of catalytic activity