Version 5.4
Homo sapiens Gene: RGS1
Summary
InnateDB Gene IDBG-105443.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS1
Gene Name regulator of G-protein signaling 1
Synonyms 1R20; BL34; HEL-S-87; IER1; IR20
Species Homo sapiens
Ensembl Gene ENSG00000090104
Encoded Proteins
IDBP-105445
regulator of G-protein signaling 1
IDBP-721984
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192575727-192580031
Strand Forward strand
Band q31.2
Transcripts
ENST00000367459 ENSP00000356429
ENST00000474373
ENST00000469578 ENSP00000464323
ENST00000462589
ENST00000498352
ENST00000583155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005516 calmodulin binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026358
View Gene Order
ENSBTAG00000021672
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
Cross-References
SwissProt Q08116
TrEMBL A0A024R945 V9HW15
UniProt Splice Variant
Entrez Gene 5996
UniGene Hs.603797 Hs.75256
RefSeq NM_002922
HUGO HGNC:9991
OMIM 600323
CCDS CCDS1375
HPRD
IMGT
EMBL AF493925 AK303138 AK315607 AL136987 BC015510 BT006668 CH471067 EU668340 S59049 X73427
GenPept AAB26289 AAH15510 AAM12639 AAP35314 ACF94493 BAG37976 BAG64242 CAA51826 CAC19805 EAW91226 EAW91228
RNA Seq Atlas 5996

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca