InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs1

Summary

InnateDB Gene

IDBG-197178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs1

Gene Name

regulator of G-protein signaling 1

Synonyms

BL34

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026358

Encoded Proteins

IDBP-788950

regulator of G-protein signaling 1

IDBP-620127

regulator of G-protein signaling 1

IDBP-788951

regulator of G-protein signaling 1

IDBP-620128

regulator of G-protein signaling 1

IDBP-788949

regulator of G-protein signaling 1

IDBP-788953

regulator of G-protein signaling 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090104:
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:144242296-144249242

Strand

Reverse strand

Band

Transcripts

ENSMUST00000167317	ENSMUSP00000139778
ENSMUST00000170870
ENSMUST00000172388	ENSMUSP00000130339
ENSMUST00000167812	ENSMUSP00000140300
ENSMUST00000169409	ENSMUSP00000126270
ENSMUST00000169042
ENSMUST00000189061	ENSMUSP00000140624
ENSMUST00000185714	ENSMUSP00000140902
ENSMUST00000189916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity