InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOXA11

Summary

InnateDB Gene

IDBG-10564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXA11

Gene Name

homeobox A11

Synonyms

HOX1; HOX1I

Species

Homo sapiens

Ensembl Gene

ENSG00000005073

Encoded Proteins

IDBP-10566

homeobox A11

IDBP-603740

homeobox A11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:27181510-27185223

Strand

Reverse strand

Band

p15.2

Transcripts

ENST00000006015	ENSP00000006015
ENST00000517402	ENSP00000448962

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001759	organ induction
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0007501	mesodermal cell fate specification
GO:0008584	male gonad development
GO:0009653	anatomical structure morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0010720	positive regulation of cell development
GO:0030326	embryonic limb morphogenesis
GO:0032330	regulation of chondrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0042733	embryonic digit morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048589	developmental growth
GO:0060065	uterus development
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060351	cartilage development involved in endochondral bone morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0032993	protein-DNA complex
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038210

View Gene Order

ENSBTAG00000014738

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.249171

RefSeq

NM_005523

HUGO

OMIM

CCDS

CCDS5411

HPRD

00846

IMGT

EMBL

GenPept

RNA Seq Atlas